Cytogenetic study of 1780 cases of spontaneous abortion.
- Author:
Wei-Ping QIAN
1
;
Yu-Mei TAN
;
Dan SONG
;
Yue-Qiu TAN
;
Guang-Xiu LU
Author Information
1. Reproductive Medical Center, Luohu Hospital, Shenzhen 518001, China.
- Publication Type:Journal Article
- MeSH:
Abortion, Spontaneous;
genetics;
pathology;
Adult;
Chromosome Aberrations;
Cytogenetic Analysis;
Female;
Humans;
Karyotyping;
Pregnancy;
Prenatal Diagnosis;
Translocation, Genetic
- From:
Journal of Central South University(Medical Sciences)
2005;30(3):258-260
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the relationship between chromosome anomaly and spontaneous abortion, and to provide useful information for genetic counseling and prenatal diagnosis in reproductive clinic.
METHODS:A total of 1 780 patients who had a history of spontaneous abortion before 24 weeks of gestation were enrolled. The lymphocyte culture and harvest were performed according to standard methods. Karyotypes were analyzed by G-banding in all cases and C- banding in some cases in addition.
RESULTS:Altogether 57 abnormal karyotypes were found and the overall incidence of chromosomal abnormalities was 3.20% (women 3.32%; men 2.12%). Among them 23 cases were the balanced translocation; 14 cases were the Robertsonian translocation, 3 cases were the complex chromosomal rearrangement, and the other 17 cases were the other abnormalities. In women with 1, 2, 3 or more spontaneous abortion, the incidence of chromosomal abnormalities was 1.7%, 2.3%, and 5.8%, respectively.
CONCLUSION:Translocations are the major abnormal karyotpes associated with spontaneous abortions. The chance of finding chromosomal aberration increases with the number of abortions. Chromosomal abnormalities are more common in women with 3 or more spontaneous abortions.
