Evaluation of tumor necrosis factor-alpha and tumor necrosis factor-beta in serum of patients with endometriosis.
- Author:
Min LUO
1
;
Yuan-Li HE
;
Dong-Xian PENG
;
Mu-Biao LIU
;
Yan-Ying CHEN
Author Information
1. Department of Obstetrics and Gynecology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Endometriosis;
blood;
surgery;
Female;
Follow-Up Studies;
Humans;
Laparoscopy;
Lymphotoxin-alpha;
blood;
Tumor Necrosis Factor-alpha;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2005;30(3):304-306
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the levels of tumor necrosis factor-alpha (TNF-alpha) and tumor necrosis factor-beta (TNF-beta) before and after conservative laparoscopic surgery in patients with endometriosis.
METHODS:The levels of TNF-alpha and TNF-beta in the serum of both 82 patients with EMS and 68 controls were determined by ELISA.
RESULTS:The levels of TNF-alpha and TNF-beta in the serum of patients with EMS were significantly higher than those of the controls (P < 0.01), and they increased with the clinical terms ( P < 0.05). After clearance of endometrosis foci with laparoscopic conservative surgery, the TNF-alpha levels decreased significantly in EMS III - IV, and TNF-beta levels decreased significantly in EMS I - IV.
CONCLUSION:Measuring TNF-alpha and TNF-beta levels in the serum of patients with EMS may have important value in postoperative follow-up, surveillance and evaluation of the effectiveness of the surgery.
