Expressions of survivin and nm23 and the relationship among the expressions and the axillary lymph node metastasis in breast cancer.
- Author:
Jie MAO
1
;
Jian HAI
;
Heng-Ping SHU
;
Yu-Hui WU
;
Hui-Yin OU
;
Sha-Yang LUO
;
Shou-Man WANG
Author Information
1. Department of Breast Surgery, Xiangya Hospital of Central South University, Changsha, Hunan. maojie1166@sina.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Axilla;
Biomarkers, Tumor;
Breast Neoplasms;
metabolism;
pathology;
surgery;
Female;
Humans;
Inhibitor of Apoptosis Proteins;
Lymph Nodes;
pathology;
Lymphatic Metastasis;
Mastectomy;
Microtubule-Associated Proteins;
biosynthesis;
genetics;
Middle Aged;
NM23 Nucleoside Diphosphate Kinases;
Neoplasm Proteins;
biosynthesis;
genetics;
Nucleoside-Diphosphate Kinase;
biosynthesis;
genetics;
Prognosis;
Retrospective Studies;
Survivin
- From:
Journal of Central South University(Medical Sciences)
2005;30(3):312-334
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expressions of Survivin protein and nm23 protein and the relationship among the expressions and axillary lymph node metastasis in breast cancer.
METHODS:The expression of Survivin and nm23 in 80 cases of breast cancer tissues were detected by immunohistochemistry SP method, and their correlation with axillary lymph node metastasis and 5-year disease free survival (DFS) were analysed.
RESULTS:Survivin protein positive expression rate was 68.75% (55/80) in breast cancer tissues, which had positive correlation with the axillary lymph nodes metastasis but negative correlation with 5 years FS (P < 0.05); nm23 protein expression had negative correlation with the axillary lymph nodes metastasis but positive to 5 years FS (P < 0.05). Survivin and nm23 proteins expression had no obvious correlation with the breast cancer pathology type, patient age and clinical stage (P > 0.05).
CONCLUSION:The anti-apoptosis effect of Survivin protein and the anti-metastasis effect of nm23 protein may be important in the occurrence and advancement of breast cancer, suggesting that it may be a new indicator of prognostic and judgement in breast cancer.
