No Association between Tumor Necrosis Factor-alpha Gene Polymorphisms and Lung Cancer Risk.
- Author:
Jin Hee KIM
1
;
Yun Chul HONG
Author Information
1. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. ychong1@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Lung cancer risk;
Polymorphism;
Tumor necrosis factor-alpha
- MeSH:
Body Mass Index;
Genotype;
Haplotypes;
Inflammation;
Lung Neoplasms*;
Lung*;
Polymorphism, Genetic;
Polymorphism, Single Nucleotide;
Smoke;
Smoking;
Tumor Necrosis Factor-alpha*
- From:Environmental Health and Toxicology
2013;28(1):e2013012-
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: The role of genetic polymorphisms of tumor necrosis factor-alpha (TNF-alpha) for lung cancer development was evaluated. METHODS: Genotypes of the TNF-alpha polymorphisms, -1210C>T, -487A>G, -417A>G, IVS1+123G>A, and IVS3+51A>G, were determined in 616 lung cancer cases and 616 lung cancer-free controls. RESULTS: After adjusting for body mass index and smoking, each TNF-alpha genotype or haplotype composed of five TNF-alpha single nucleotide polymorphisms did not show an association with lung cancer risk (p>0.05). The statistical power was found to be 88.4%, 89.3%, 93.3%, 69.7%, and 93.9% for 1210C>T, -487A>G, -417A>G, IVS1+123G>A, and IVS3+51A>G, respectively. Furthermore, the effects of each SNP or haplotype on lung cancer risk were not found to be different according to the cell type of lung cancer (p>0.05). In the repeated analysis with only subjects without other diseases related to inflammation, there was also no association between polymorphisms or haplotypes of the TNF-alpha gene and lung cancer risk (p>0.05). CONCLUSIONS: This study found no association between common variants of the TNF-alpha gene and lung cancer risk.
