Role of Nrf2/HO-1 signal axis in the mechanisms for oxidative stress-relevant diseases.
10.11817/j.issn.1672-7347.2019.01.012
- Author:
Tiantian WANG
1
,
2
;
Chunyuan CHEN
3
;
Lei YANG
4
,
5
,
6
;
Zhihui ZENG
1
,
7
;
Maojun ZENG
3
;
Wen JIANG
3
;
Lin LIU
3
;
Mingyi ZHAO
3
Author Information
1. Department of Pediatrics, Third Xiangya Hospital, Central South University, Changsha 410013
2. Department of Clinical Medicine, Xiangya School of Medicine, Central South University, Changsha 410013, China.
3. Department of Pediatrics, Third Xiangya Hospital, Central South University, Changsha 410013, China.
4. Guangdong Cardiovascular Institute
5. Department of Cardiovascular Surgery, Guangdong General Hospital
6. Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
7. Department of Pediatrics, Maternal and Child Health Hospital of Changde City, Changde Hunan 415000, China.
- Publication Type:Journal Article
- MeSH:
Heme Oxygenase-1;
NF-E2-Related Factor 2;
Oxidative Stress;
Reactive Oxygen Species;
Signal Transduction
- From:
Journal of Central South University(Medical Sciences)
2019;44(1):74-80
- CountryChina
- Language:Chinese
-
Abstract:
In the development of oxidative stress-relevant diseases, reactive oxygen species (ROS) removal obstacle or excess production results in the damage of the body tissues and organs. Recent studies have demonstrated that nuclear factor E2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) axis played a significant role in anti-oxidative stress. The Nrf2/HO-1 axis counteracts oxidative stress injury by its resistance to inflammation, oxidation, mitochondrial damage and calcium influx, apoptosis, pyroptosis, ferroptosis and autophagy, which provides a theoretical basis for its therapeutic effect on various oxidative stress-relevant diseases in multiple organs (respiratory, cardiovascular, nervous, digestive, urinary and blood systems). Therefore, effective regulation of the Nrf2/HO-1 signal axis can be an important strategy for treatment of oxidative stress-relevant diseases.
