Structure and function of DJ-1 and its role in Parkinson's disease.
10.11817/j.issn.1672-7347.2019.01.017
- Author:
Chuxin HUANG
1
,
2
;
Lixia QIN
3
;
Hainan ZHANG
4
Author Information
1. Department of Neurology, Second Xiangya Hospital, Central South University, Changsha 410011
2. Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
3. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
4. Department of Neurology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Dopaminergic Neurons;
Mice;
Oncogene Proteins;
Oxidative Stress;
Parkinson Disease;
Protein Deglycase DJ-1;
Substantia Nigra
- From:
Journal of Central South University(Medical Sciences)
2019;44(1):105-111
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease (PD) is a neurodegenerative movement disorder mainly due to degeneration of dopaminergic neurons in the substantia nigra. Most PD cases are sporadic and only 5%-10% of patients carry mutations with inheritance. Among them, the mutation of DJ-1 is related to the autosomal recessive early-onset parkinsonism. DJ-1, the Parkinson's disease-related protein, plays important roles in different physiopathological processes, including oxidative stress, cell translocation and regulation of transcription and translation. DJ-1 is known to be widely expressed in different areas of brain, including hippocampus, amygdala, substantia nigra and cortical areas. Several researchers have tried to demonstrate the clinical and neuroimaging features of DJ-1 related parkinsonism. The DJ-1 knockout mouse model was established to further explore the mechanisms of different functions. Moreover, the search for different forms of DJ-1 as potential biomarkers of PD also provides guidance for its accurate diagnosis and treatment in the future.
