Correlation between estrogen receptor β and ABCC11 gene single nucleotide polymorphisms and axillary osmidrosis.
10.11817/j.issn.1672-7347.2019.03.015
- Author:
Rulong HU
1
;
Yu GUO
1
;
Jianhong LONG
1
Author Information
1. Department of Plastic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
ATP-Binding Cassette Transporters;
genetics;
Axilla;
Estrogen Receptor beta;
genetics;
Genotype;
Humans;
Polymorphism, Single Nucleotide
- From:
Journal of Central South University(Medical Sciences)
2019;44(3):329-333
- CountryChina
- Language:Chinese
-
Abstract:
To explore the correlation between single nucleotide polymorphisms (SNPs) of hormone receptor gene or other related genes and axillary osmidrosis (AO).
Methods: Whole blood samples of 219 patients with AO and 159 normal people were collected, and their genomic DNA was extracted. SNPs of 49 selected gene loci were detected and analyzed by using matrix-assisted laser analysis and ionization time of flight mass spectrometry and other related technologies.
Results: There were significant differences in SNPs at rs1256061 of estrogen receptor β gene and rs17822931, rs16945916 and rs62058521 in ABCC11 gene between the AO patients and normal people (all P<0.01). 81.1% of patients with AO carried G allele at rs1256061, while only 63.2% of normal people carried G allele; 96.3% of patients with AO carried G allele at rs17822931, while only 4.4% of the normal people carried G allele; 28.6% of the patients with armpit odor carried the G allele of rs16945916, while only 0.6% of the normal people carried G allele; 28.0% of patients with AO carried G allele at rs62058521, while only 0.6% of the normal people carried G allele.
Conclusion: SNPs of rs1256061 at the locus of estrogen receptor gene are correlated with the pathogenesis of AO, while SNPs at multiple loci (rs16945916, rs62058521 and rs17822931) in ABCC11 gene are correlated with the pathogenesis of AO.
