Research advances in TET enzyme and its intermediate product 5hmC.
10.11817/j.issn.1672-7347.2019.04.017
- Author:
Jingni WU
1
;
Xiaoling FANG
1
;
Xiaomeng XIA
1
;
Mengmeng ZHANG
1
Author Information
1. Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
5-Methylcytosine;
metabolism;
Cell Differentiation;
DNA;
DNA Methylation;
DNA-Binding Proteins;
Epigenesis, Genetic;
Humans
- From:
Journal of Central South University(Medical Sciences)
2019;44(4):449-454
- CountryChina
- Language:Chinese
-
Abstract:
DNA methylation is a significant epigenetic modification mode, which plays an important role in embryo reprogramming, stem cell differentiation and tumor occurrence. The ten-eleven translocation (TET) enzyme is a crucial demethylation enzyme, which can catalyze 5-methylcytosine(5mC) to 5-hydroxymethylcytosine(5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine(5caC). These bases represent the epigenetic modifications of DNA and regulate the process of DNA methylation. Understanding the role of TET enzyme in regulating the DNA methylation modification and gene expression can help us to gain the knowledge for the normal growth development and epigenetic regulation in human diseases.
