Magnetic resonance imaging features of glioma with Brg/Brm associated factor 53a expression.
10.11817/j.issn.1672-7347.2019.05.003
- Author:
Li MENG
1
;
Xiaoyi WANG
1
;
Qiongqiong HE
2
;
Tingting GUAN
1
;
Zaide HAN
1
;
Wu XING
1
Author Information
1. Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.
2. Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Actins;
metabolism;
Brain Neoplasms;
Chromosomal Proteins, Non-Histone;
metabolism;
DNA-Binding Proteins;
metabolism;
Glioma;
Humans;
Magnetic Resonance Imaging;
Necrosis
- From:
Journal of Central South University(Medical Sciences)
2019;44(5):485-490
- CountryChina
- Language:Chinese
-
Abstract:
To explore the magnetic resonance imaging (MRI) characteristics of glioma with Brg/Brm-associated factor 53a (BAF53a) expression.
Methods: A total of 121 patients with glioma was divided into a BAF53a high expression group (n=79) and a low expression group (n=42) according to the results of immunohistochemistry. Then the MRI characteristics, including lesion location, number, boundary, maximum diameter, peripheral edema, midline structure shift, homogeneity, cystic necrosis, hemorrhage, strengthening degree, ependymal strengthening, pia mater enhancement, deep white matter invasion and lesion across the midline (total 14 items), were analyzed.
Results: The results showed that there were significance difference in lesion border, lesion edema, enhancement of the lesion, and deep white matter invasion between the 2 groups (all P<0.05).
Conclusion: The MRI characteristics, such as lesion border, lesion edema degree, enhancement degree of the lesion and deep white matter invasion, might be associated with BAF53a expression in gliomas.
