Imaging changes in brain microstructural in long-term abstinent from methamphetamine-dependence.
10.11817/j.issn.1672-7347.2019.05.004
- Author:
Lidan FAN
1
;
Qingqing ZHANG
2
;
Shengxiang LIANG
3
,
4
;
Huabing LI
1
;
Zhong HE
1
;
Jianning SUN
1
;
Weijun SITU
1
;
Zhixue ZHANG
5
;
Dawei WU
2
;
Zishu ZHANG
1
;
Zhifeng KOU
6
,
7
;
Jun ZHANG
8
;
Jun LIU
1
Author Information
1. Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
2. College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
3. National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
4. Fujian Key Laboratory of Rehabilitation Technology, Fuzhou 350122, China.
5. Department of Radiology, First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China.
6. Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011, China
7. Department of Biomedical Engineering and Radiology, Wayne State University, Detroit MI 48201, USA.
8. Hunan Judicial Police Vocational College, Changsha 410131, China.
- Publication Type:Journal Article
- MeSH:
Amphetamine-Related Disorders;
Anisotropy;
Brain;
Diffusion Tensor Imaging;
Humans;
Methamphetamine
- From:
Journal of Central South University(Medical Sciences)
2019;44(5):491-500
- CountryChina
- Language:Chinese
-
Abstract:
To explore the mechanism for changes in brain microstructure in long-term abstinent from methamphetamine-dependence by using the diffusion tensor imaging (DTI).
Methods: A total of 26 patients with long-term abstinent methamphetamine-dependence, whose abstinence time more than 14 months, and 26 normal controls all underwent cognitive executive function tests and DTI scans. We used voxel-based analysis to compare the fractional anisotropy (FA) and mean diffusivity (MD) to obtain the abnormal brain regions of DTI parameters between the two groups. Spearman correlation analysis was used to explore the correlation between FA, MD of the brain regions with abnormal parameters and cognitive executive function tests.
Results: There were no statistical differences in the cognitive executive function tests between the two groups (P>0.05). Compared with the normal control group, the long-term abstinent from methamphetamine-dependence group showed the decreased FA in the right precuneus, right superior frontal gyrus, right calcarine, left inferior temporal gyrus and the increased MD in the right triangular part of inferior frontal gyrus, right precuneus, right posterior cingulate, right middle temporal gyrus, bilateral middle occipital gyrus, left superior parietal lobule, and lobule VIII of cerebellar hemisphere. The MD values of the right middle temporal gyrus in the long-term abstinent group were negatively correlated with the number of completions within 60 seconds (r=-0.504) and within 120 seconds (r=-0.464) .
Conclusion: The DTI parameters in multiple brain regions from the methamphetamine-dependence patients are still abnormal after a long-term abstinence. DTI can provide imaging evidence for brain microstructural abnormalities in long-term abstinent from methamphetamine-dependence.
