Progress in the role of ω-3 PUFAs in regulating the genesis and development of colorectal cancer.
10.11817/j.issn.1672-7347.2019.05.017
- Author:
Si FENG
1
;
Li ZHANG
1
;
Wei XIE
1
;
Zhongcheng KANG
1
;
Pan CHEN
1
Author Information
1. Department of Hepatobiliary Surgery, Hunan Cancer Hospital/Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Cell Proliferation;
Colorectal Neoplasms;
Fatty Acids, Omega-3;
Humans;
Tumor Microenvironment
- From:
Journal of Central South University(Medical Sciences)
2019;44(5):588-595
- CountryChina
- Language:Chinese
-
Abstract:
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are a class of bioactive polyunsaturated fatty acids with inhibitory effects on colorectal cancer. Firstly, ω-3 PUFAs can change membrane fluidity and affect cell functions; Secondly, they can affect the activity of important proteins in cell signal transduction pathways and regulate the inflammatory mediators and the functions of immune cells in the tumor microenvironment; Finally, they can change the important molecules in the process of tumor metastasis and inhibit the colorectal cancer via suppressing cell proliferation, promoting apoptosis, enhancing antitumor immunity, and preventing tumor metastasis.
