Progress in study on the role of metabolomics in toxic effects of environmental pollutants and the underlying mechanism.
10.11817/j.issn.1672-7347.2019.06.013
- Author:
Jin FU
1
;
Jian'an HU
1
Author Information
1. Department of Occuapational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha 410078, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Benzo(a)pyrene;
Environmental Pollutants;
Metabolomics;
Oxidative Stress
- From:
Journal of Central South University(Medical Sciences)
2019;44(6):692-700
- CountryChina
- Language:Chinese
-
Abstract:
Metabolomics methods were applied in the study of the toxicity of environmental pollutants. It has been shown that exposure to heavy metals such as mercury, arsenic, cadmium, chromium and lead could cause significant changes in energy, lipids, nucleic acids and amino acids in mammalian cells. After exposure to benzo(a)pyrene [B(a)P], the glands of Pinctada pumila could produce various changes, such as energy metabolic disorder, cell damage, signal transduction disorder, oxidative stress and osmotic disorder. Persistent organic compounds polychlorinated biphenyls (PCBs) could exert toxic effects on Zebrafish embryos through affecting amino acid metabolism, DNA and protein methylation and biosynthesis. After exposure to endocrine disruptors, such as nonylphenol, octylenediester phthalate and bisphenol propane, goldfish showed energy, lipid and nucleic acid metabolic disorders.
