White matter integrity in patients with mild cognitive impairment complicated with lacunar infarctions by diffusion tensor imaging.
10.11817/j.issn.1672-7347.2019.190095
- Author:
Tingting YU
1
,
2
;
Zhenyu YIN
3
;
Bing ZHANG
4
;
Weiping LI
4
;
Yun XU
1
,
5
;
Hong ZHOU
6
Author Information
1. Department of Neurology, Drum Tower Hospital of Nanjing Medical University, Nanjing 210008
2. Department of Geriatrics, Affliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
3. Department of Geriatrics, Affliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
4. Department of Radiology, Affliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
5. Department of Neurology, Affliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
6. Department of Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China.
- Publication Type:Journal Article
- MeSH:
Anisotropy;
Brain;
Cognitive Dysfunction;
diagnostic imaging;
Diffusion Magnetic Resonance Imaging;
Diffusion Tensor Imaging;
Humans;
Neuropsychological Tests;
Stroke, Lacunar;
White Matter
- From:
Journal of Central South University(Medical Sciences)
2019;44(7):805-812
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the white-matter integrity and its correlation with cognitive function in patients with mild cognitive impairment (MCI) complicated with lacunar infarctions (LI) by diffusion tensor imaging (DTI) of magnetic resonance (MR).
Methods: Twenty-six patients with MCI were selected including 14 patients with combined LI and 12 patients without combined LI, and 16 healthy volunteers were recruited as normal control. All subjects completed cognitive function assessment and DTI sequence of MR. Factional anisotropy (FA) and mean diffusivity (MD) values among the MCI with LI group (MCI-LI), the MCI without LI group (MCI-non LI), and the normal control group (NC) were compared, and the correlation between DTI parameters and cognition was determined by multiple linear stepwise regression.
Results: Compared with the MCI-non LI group, the FA values were significantly decreased (P<0.05) and MD values were significantly increased (P<0.05) in the white matter fiber bundles (such as the left hippocampus of the cingulate tract, the frontal fascicle of the corpus callosum, the right inferior frontal occipital fascicle, and the right superior longitudinal fascicle) in the MCI-LI group. In the MCI-LI group, the FA value of right cingulate gyrus was significantly correlated with Activity of Daily Living Scale (ADL) score (B=-50.2, 95% CI -77.7 to -22.7, P=0.003); the FA value of left anterior thalamic radiation (B=443.8, 95% CI 222.9 to 664.8, P=0.001) and MD value of left inferior longitudinal tract (B=-318.5, 95% CI -534.7 to -102.3, P=0.009) were significantly correlated with Wechsler digit symbol substitution (WDSS) score; the FA value of left superior temporal lobe longitudinal tract was significantly correlated with Backward Digit Span (BDSP) score (B=12.5, 95% CI 1.5 to 23.4, P=0.030).
Conclusion: The integrity of white matter is significantly destroyed in MCI patients with LI than that in MCI patients without LI, and there is a correlation between cognitive function and DTI parameters in some white matter tracts in MCI patients with LI.
