Clinical features for hospitalized type 1 diabetic patients with different ages of onset.
10.11817/j.issn.1672-7347.2019.180541
- Author:
Ting HU
1
,
2
,
3
;
Ying CHENG
1
,
4
;
Gan HUANG
1
,
4
;
Xia LI
1
,
4
;
Zhiguang ZHOU
1
,
4
;
Lin YANG
1
,
4
Author Information
1. Department of Metabolic Endocrinology, Second Xiangya Hospital, Central South University, Key Laboratory of Diabetes Immunology, Ministry of Education
2. National Clinical Research Center for Metabolic Diseases, Changsha 410011
3. Department of General Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China).
4. National Clinical Research Center for Metabolic Diseases, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
C-Peptide;
Diabetes Mellitus, Type 1;
Diabetes Mellitus, Type 2;
Diabetic Nephropathies;
Female;
Humans;
Male;
Retrospective Studies;
Risk Factors;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2019;44(7):813-817
- CountryChina
- Language:Chinese
-
Abstract:
To explore the clinical features and complications of 545 hospitalized type 1 diabetic patients.
Methods: All data of 545 patients with typical type 1 diabetes (T1DM) who were hospitalized in the Department of Endocrinology, the Second Xiangya Hospital, Central South University were collected. The data were analyzed retrospectively to explore the clinical features and complications. Clinical and biochemical characteristics were analyzed through comparison between different subgroups according to the onset age (≤13 years old, 14-29 years old, ≥30 years old).
Results: The median onset age of T1DM patients was 27.0 (15.0, 40.0) years, and the middle-onset was 42.1%. Among the 3 groups, the proportion of female (58.0%) was the highest in the ≤13 years old group, concomitant with the lowest SBP and serum creatinine levels as well as the lowest incidence of all microvascular complications (21.0% of diabetic nephropathy, 23.3% of diabetic retinopathy, 34.1% of diabetic peripheral neuropathy; all P<0.05). Moreover, the fasting C peptide and peak C peptide levels were the lowest in ≥30 years old group compared with the other two groups, and the incidence of ketosis (33.5%) and all macrovascular complications were the highest among the three groups (all P<0.05).
Conclusion: There are about half of the hospitalized patients with T1DM whose onset ages are ≥30 years. The incidence of ketosis at the onset and the risk for various microvascular and macrovascular complications after onset are higher than those with the onset age <30 years.
