Epigenetic research progress in colorectal cancer.
10.11817/j.issn.1672-7347.2019.190087
- Author:
Lu QIN
1
;
Anding KANG
1
Author Information
1. Department of Colorectal Surgery, Hunan Cancer Hospital & Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Colorectal Neoplasms;
genetics;
DNA Methylation;
Epigenesis, Genetic;
Epigenomics;
Histones;
Humans
- From:
Journal of Central South University(Medical Sciences)
2019;44(7):830-836
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is one of the common malignant tumors, which seriously threatens human health. Its morbidity and mortality rank the third and the second among all malignant tumors. The progress of colorectal cancer is a complex process involving the accumulation of genetic and epigenetic changes. Epigenetic changes of colorectal cancer mainly include DNA methylation, histone modification, non-coding RNAs (such as microRNAs and lncRNAs), which are of great significance to early diagnosis and prognosis evaluation, and to chemosensitivity assessment for colorectal cancer, providing a new thought for the treatment of colorectal cancer.
