Current status for animal models of intensive care unit acquired muscle weakness.
10.11817/j.issn.1672-7347.2018.06.018
- Author:
Wenmao ZOU
1
;
Furong LIU
1
;
Jinghui LI
1
Author Information
1. Department of Critical Care Medicine, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208 , China.
- Publication Type:Journal Article
- MeSH:
Animals;
Critical Illness;
Disease Models, Animal;
Humans;
Intensive Care Units;
Muscle Weakness;
etiology;
mortality;
Muscle, Skeletal;
physiopathology;
Prognosis;
Quality of Life;
Reproducibility of Results;
Survival Rate
- From:
Journal of Central South University(Medical Sciences)
2018;43(6):691-696
- CountryChina
- Language:Chinese
-
Abstract:
Intensive care unit acquired muscle weakness (ICU-AW) is a neuromuscular complication secondary to severe illness. The essence for this disease is skeletal muscle dysfunction. With the development of medical technology, the survival rate for severe patients has been significantly improved. The long term complications for the severe patients with ICU-AW are getting more and more common, and they seriously affect the quality of life and prognosis of patients. However, the current treatment is ineffective. Establishment of ICU-AW animal model is an important way to study the pathogenesis and intervention targets for this disease. There are many risk factors for this disease, and the principles for ICU-AW animal models are not the same at home and abroad, and the methods of preparation are different. The choice of a reasonable animal model is important for the reliability of the results.
