Biological roles of adenosine deaminase acting on RNA and their relationship with human diseases.
10.11817/j.issn.1672-7347.2018.08.014
- Author:
Kezhu CHEN
1
;
Ruze MA
1
;
Fang WANG
1
Author Information
1. Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Adenosine;
metabolism;
Adenosine Deaminase;
physiology;
Base Sequence;
Creatinine;
metabolism;
Deamination;
Disease;
etiology;
Humans;
RNA Editing;
physiology;
RNA, Double-Stranded;
RNA-Binding Proteins;
physiology
- From:
Journal of Central South University(Medical Sciences)
2018;43(8):904-911
- CountryChina
- Language:Chinese
-
Abstract:
RNA editing, especially A-to-I RNA editing, is a common post-transcriptional modification in mammals. Adenosine deaminase acting on RNA (ADAR) is a key protein for A-to-I editing, which converts the adenosine group of a double-stranded RNA to creatinine group by deaminating it, resulting in a change of nucleotide sequence. There are 3 types of ADARs (ADAR1, ADAR2, ADAR3) that have been found in recent years. The abnormalities of ADARs are closely related to many human diseases such as viral infections, metabolic diseases, nervous system diseases, and tumors.
