Research progress of long noncoding RNA in regulating adipogenesis.
10.11817/j.issn.1672-7347.2018.08.015
- Author:
Haoneng TANG
1
,
2
,
3
,
4
;
Yaru CHEN
1
,
2
,
5
;
Houde ZHOU
1
,
2
,
5
Author Information
1. Institute of Metabolism and Endocrinology
2. Hunan Key Laboratory for Metabolic Bone Disease
3. National Clinical Research Center for Metabolic Diseases
4. Department of Laboratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.
5. National Clinical Research Center for Metabolic Diseases, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Adipogenesis;
genetics;
Epigenesis, Genetic;
Gene Expression Regulation;
Humans;
RNA, Long Noncoding;
physiology;
RNA, Untranslated
- From:
Journal of Central South University(Medical Sciences)
2018;43(8):912-919
- CountryChina
- Language:Chinese
-
Abstract:
Long noncoding RNA (lncRNA) is once thought to be the genome transcriptional "noise". However, it has received considerable attention in the past few years and is emerging as potentially important player in biological regulation. Recent studies have revealed that increasing number of lncRNA plays pivotal roles in regulating the gene expression which involves in the development of the human disease. Functions of lncRNA include 3 types of interaction: RNA-RNA, RNA-DNA, and RNA-protein, which may participate in gene expression regulation through epigenetic modifications, transcriptional regulation, post-transcriptional regulation, acting as biological media. Due to the prevalence of obesity and related diseases, some attempts have been done to explore the pathogenesis of obesity from the field of noncoding RNA. Several lncRNAs have been identified to be involved in the regulation of the adipogenesis (white adipose tissue and brown adipose tissue) and energy metabolism. In this review, we summarized recent advances of lncRNAs to provide a new sight for the mechanism of obesity.
