Recent progress in smooth muscle autophagy of vascular diseases.
10.11817/j.issn.1672-7347.2018.08.016
- Author:
Shi TAI
1
;
Qin ZHOU
2
;
Yanan GUO
1
;
Shenghua ZHOU
1
Author Information
1. Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
2. Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Autophagy;
physiology;
Cell Survival;
Cellular Senescence;
Disease Progression;
Humans;
Muscle, Smooth, Vascular;
cytology;
Myocytes, Smooth Muscle;
physiology;
Vascular Diseases;
pathology;
therapy
- From:
Journal of Central South University(Medical Sciences)
2018;43(8):920-928
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy plays a crucial role in maintaining normal structure and vascular function in vivo. When stress-relevant stimuli are involved, the increases of autophagy can protect vascular smooth muscle cells, promote cell survival, and phenotype transformation, as well as reduce calcification. On the contrary, the decrease of autophagy can accelerate cell senescence, resulting in structural changes and dysfunction of vasomotor and vasodilation. However, excessive activation of autophagy can induce the damage of the healthy protein and essential organelles, and even lead to autophagic cell death, accelerating the progression of vascular disease. Thus, the precise targeting of autophagy opens a novel way for treatment of vascular diseases.
