Association of short-term efficacy for infliximab in rheumatoid arthritis with plasma concentration and anti-drug antibody.

Meiyan Song; Fen LI; Xi Xie; Jian Chen; Mengshi Tang; Jing Tian; Jinfeng DU; Yan GE; Shu LI; Suqing XU

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Association of short-term efficacy for infliximab in rheumatoid arthritis with plasma concentration and anti-drug antibody.

Author: Meiyan SONG ¹ ; Fen LI ¹ ; Xi XIE ¹ ; Jian CHEN ¹ ; Mengshi TANG ¹ ; Jing TIAN ¹ ; Jinfeng DU ¹ ; Yan GE ¹ ; Shu LI ¹ ; Suqing XU ¹
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1. Department of Rheumatology and Immunology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Publication Type:Clinical Trial
MeSH: Antibodies, Monoclonal; blood; Antirheumatic Agents; therapeutic use; Arthritis, Rheumatoid; drug therapy; Drug Therapy, Combination; Humans; Infliximab; blood; therapeutic use; Treatment Outcome; Tumor Necrosis Factor-alpha; blood
From: Journal of Central South University(Medical Sciences) 2018;43(9):982-986
CountryChina
Language:Chinese
Abstract: To investigate the correlation between peripheral concentration of infliximab (IFX) or anti-IFX antibody titers and short-term therapeutic effect of IFX in patients with active rheumatoid arthritis (RA).  Methods: Twenty patients with active RA were treated with combination of methotrexate (MTX), leflunomide (LEF) with IFX, and the clinical and laboratory index and the side effects were recorded before and after IFX treatment. Twenty healthy subjects were chosen as a control group.  Results: After 14-week treatment, patients were categorized into good, moderate or no responders according to EULAR remission criteria. There were no significant differences in peripheral IFX concentration, anti-IFX antibody titers and TNF-α levels among the 3 groups, and there were no significant correlations among ΔDAS28-CRP, peripheral IFX concentration, anti-IFX antibody titers and TNF-α levels.  Conclusion: Peripheral IFX concentration, anti-IFX antibody titers and TNF-α levels can not be used as reliable predictive index for short-term effect of IFX in active RA.