Role of cofilin in kidney disease.
10.11817/j.issn.1672-7347.2018.10.018
- Author:
Xiejia LI
1
,
2
;
Hong LIU
1
,
2
Author Information
1. Department of Nephrology, Second Xiangya Hospital, Central South University
2. Hunan Key Laboratory of Kidney Disease and Blood Purifi cation, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Cofilin 1;
metabolism;
Glomerulosclerosis, Focal Segmental;
physiopathology;
Humans;
Kidney;
physiopathology;
Kidney Diseases;
physiopathology;
Proteinuria;
genetics;
physiopathology
- From:
Journal of Central South University(Medical Sciences)
2018;43(10):1159-1163
- CountryChina
- Language:Chinese
-
Abstract:
Cofilin is a actin-binding protein in eukaryotic cells. It plays a role in maintaining the steady state of the internal environment through regulating actin dynamics, which contributes to the development of various kinds of diseases. In recent 20 years, cofilin has been widely attracted due to its regulatory effect on cell phenotype, gene transcription, apoptosis and inflammation in renal tissue. Cofilin plays a regulatory role in pathological changes in proteinuria diseases such as minimal change nephropathy, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy. It could be one of the diagnosis index for glomerular podocyte injury. At the same time, cofilin plays a key role in maintaining the polarity and function of proximal tubular epithelial cells and it is involved in the regulation of kidney inflammation in a variety of kidney diseases, such as renal ischemia/reperfusion injury, diabetic nephropathy, and hypertensive nephropathy reaction. In addition, cofilin plays an important role in epithelial-to-mesenchymal transition (EMT) of tumor cells and epithelial cells in various tissues, suggesting that cofilin may be involved in the regulation of peritoneal dialysis-related EMT and fibrosis. Cofilin might turn into the new diagnosis and treatment target of kidney diseases.
