Research progress in AMP-activated protein kinase and sepsis-induced cardiac dysfunction.
10.11817/j.issn.1672-7347.2018.12.013
- Author:
Yamin LI
1
,
2
;
Jianfeng QIAO
1
,
2
;
Wenxuan ZHANG
3
,
4
,
5
;
Zhenyu PENG
3
,
4
,
5
Author Information
1. Department of Nursing, Second Xiangya Hospital, Central South University, Changsha 410011
2. Xiangya Nursing School, Central South University, Changsha 410013, China.
3. Department of Emergency Medicine, Second Xiangya Hospital
4. Central South University, Changsha 410011
5. Emergency Medicine and Diffi cult Diseases Institute, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
AMP-Activated Protein Kinases;
metabolism;
Apoptosis;
Autophagy;
Heart Diseases;
enzymology;
etiology;
Humans;
Sepsis;
complications
- From:
Journal of Central South University(Medical Sciences)
2018;43(12):1364-1368
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis-induced cardiac dysfunction is a serious complication of sepsis with no effective treatment. AMP-activated protein kinase (AMPK) is a regulator for energy metabolism in cells and plays a key role in the energy balance. Recent studies have shown that AMPK exerted a protective effect on sepsis-induced cardiac dysfunction, which was related to the regulation of inflammation, endothelial cells injury, energy metabolism, myocardial cells apoptosis and autophagy. Therefore, AMPK is a therapeutic target for sepsis-induced cardiac dysfunction.
