Value of magnetic resonance diffusion-weighted imaging for evaluating the inflammatory activity of perianal Crohn's fistula.
10.11817/j.issn.1672-7347.2019.02.009
- Author:
Shaojuan WANG
1
;
Xiaowen TANG
1
;
Zhongqiu WANG
1
;
Hao WANG
2
Author Information
1. Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210009, China.
2. Department of Radiology, Jiangsu Cancer Hospital, Nanjing 210029, China.
- Publication Type:Journal Article
- MeSH:
Crohn Disease;
Diffusion Magnetic Resonance Imaging;
Fistula;
Humans;
Retrospective Studies
- From:
Journal of Central South University(Medical Sciences)
2019;44(2):173-179
- CountryChina
- Language:Chinese
-
Abstract:
To explore the value of magnetic resonance diffusion-weighted imaging (MR-DWI) for evaluating inflammatory activity of perianal Crohn's fistula.
Methods: A total of 55 patients, who were diagnosed as perianal Crohn's fistula by surgery and/or endoscopy, were assessed retrospectively. All patients, underwent pelvic magnetic resonance imaging (MRI) before and 32 weeks after the treatment, were divided into 2 groups according to their response to treatment: an effective group (34 cases) and an ineffective group (21 cases). The MRI images of patients in the 2 groups were analyzed. The changes of apparent diffusion coefficient (ADC) values before and after treatment in the 2 groups were measured and compared by a paired t-test. An MRI-based score of perianal Crohn's disease severity was calculated as a reference standard, and the correlation between the ADC value and the MRI-based score was analyzed by using a Pearson correlation coefficient method.
Results: In the effective group, the ADC values after therapy were significantly greater than those before therapy (P<0.05), but in the ineffective group, there was no significant difference in the ADC value between after and before therapy (P>0.05). There was a strong negative correlation between the ADC values (after and before therapy) and the MRI-based scores in all the patients [in the effective group alone (r=-0.672, P<0.01) or in the effective group + the ineffective group (r=-0.638, P<0.01)].
Conclusion: Changes in the ADC values of perianal fistula are related to the fistula activity. MR-DWI and ADC value can accurately evaluate the inflammatory activity of perianal Crohn's fistula.
