Research advance in chondrogenic differentiation of adipose-derived stem cells.
10.11817/j.issn.1672-7347.2019.022.013
- Author:
Xiaolin JI
1
;
Kangkai WANG
2
;
Nian WANG
2
Author Information
1. Eight-year Clinical Medicine Program, Xiangya School of Medicine, Central South University, Changsha 410013, China.
2. Department of Pathophysiology, Central South University, Changsha 410078, China.
- Publication Type:Journal Article
- MeSH:
Adipocytes;
Adipose Tissue;
Cartilage, Articular;
Cell Differentiation;
Cells, Cultured;
Chondrocytes;
Chondrogenesis;
Stem Cells;
Tissue Engineering
- From:
Journal of Central South University(Medical Sciences)
2019;44(2):201-208
- CountryChina
- Language:Chinese
-
Abstract:
Articular cartilage lesions due to injury or other pathology are often difficult to heal, and the outcomes of the clinical treatment widely used today are far from satisfaction. Adipose-derived stem cells (ADSCs) are multipotent stem cells from adipose tissue. Tissue engineering based on the ability of ADSCs to differentiate into chondrocytes provides a new idea for the repair and regeneration of articular cartilage defects. The method for inducing the differentiation of ADSCs into chondrocytes in vitro who have been quite well established, which mainly include the use of growth factors and scaffolds to mimic the in vivo microenvironment, thereby promoting the differentiation of ADSCs into chondrocytes.
