Progress in the study of macrophage activation and ulcerative colitis from the Notch/NF-κB/NLRP3 signaling pathway.
10.11817/j.issn.1672-7347.2019.180693
- Author:
Shuguang YAN
1
;
Xiaofan XU
1
;
Qian LI
1
;
Yi HUI
1
;
Jingtao LI
2
;
Hailiang WEI
3
Author Information
1. College of Basic Medicine, Shanxi University of Chinese Medicine, Xianyang Shanxi 712046, China.
2. Department of Hepatology,
Affiliated Hospital, Shanxi University of Chinese Medicine, Xianyang Shanxi 712000, China.
3. Departments of General Surgery,
Affiliated Hospital, Shanxi University of Chinese Medicine, Xianyang Shanxi 712000, China.
- Publication Type:Journal Article
- MeSH:
Colitis, Ulcerative;
Cytokines;
Humans;
Macrophage Activation;
NF-kappa B;
NLR Family, Pyrin Domain-Containing 3 Protein;
Receptors, Notch;
Signal Transduction
- From:
Journal of Central South University(Medical Sciences)
2019;44(10):1174-1178
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis is an intestinal inflammatory disease characterized by diarrhea, abdominal pain and purulent stool. Uncontrolled inflammation caused by macrophage hyper-activation is an important cause of ulcerative colitis. Therefore, inhibiting macrophage hyper-activation is an effective way to treat ulcerative colitis. Notch signaling pathway is involved in regulating the immune response of macrophages and promoting inflammation. NF-κB signaling pathway is the "star pathway" involved in inflammation. NLRP3 inflammatory body is involved in the activation of macrophages. Notch, NF-κB and NLRP3 inflammatory bodies constitute the upstream and downstream signal pathways in the existing immune inflammatory diseases. Notch signal pathway can regulate the activation of macrophage via NF-κB/NLRP3 inflammatory body signaling pathway.
