Research progress in NADPH oxidase family in cardiovascular diseases.
10.11817/j.issn.1672-7347.2019.180394
- Author:
Jing CAO
1
;
Zhaoya LIU
1
;
Qian XU
1
;
Ruizheng SHI
1
;
Guogang ZHANG
1
Author Information
1. Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Cardiovascular Diseases;
Humans;
Hypertension;
NADPH Oxidases;
Oxidation-Reduction;
Oxidative Stress;
Reactive Oxygen Species
- From:
Journal of Central South University(Medical Sciences)
2019;44(11):1258-1267
- CountryChina
- Language:Chinese
-
Abstract:
Nicotinamide adenine dinucleotide phosphate oxidase (NOX) is a major source of reactive oxygen species (ROS) in the cardiovascular system. The family of NOX includes seven isoforms, and expressed in different cardiovascular cell types and cell compartments, modulating multiple functions, such as cell proliferation, migration, differentiation, apoptosis, senescence, and inflammatory responses. The NOX-derived ROS are involved in many processes associated with cardiovascular diseases, such as hypertension, atherosclerosis, diabetic vascular disease, ventricular remodeling after myocardial infarction, and so on.
