Serum Ferritin Is Differentially Associated with Anti-oxidative Status and Insulin Resistance in Healthy Obese and Non-obese Women.
10.4082/kjfm.2012.33.4.205
- Author:
Jee Yon LEE
1
;
Jae Min PARK
;
Jung Ah HONG
;
Duk Chul LEE
;
Jee Aee IM
;
Ji Won LEE
Author Information
1. Department of Family Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. indi5645@yuhs.ac
- Publication Type:Original Article
- Keywords:
Ferritins;
Obesity;
Oxidative Stress
- MeSH:
Body Mass Index;
Female;
Ferritins;
Homeostasis;
Humans;
Insulin;
Insulin Resistance;
Linear Models;
Obesity;
Oxidative Stress
- From:Korean Journal of Family Medicine
2012;33(4):205-210
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Ferritin is known to be associated with insulin resistance (IR) and oxidative stress; however, recent studies have shown that there is an association between ferritin and anti-oxidative status. To date, the biphasic response of ferritin to oxidative stress has not been fully evaluated. Thus, we investigated the association between ferritin and IR and anti-oxidative status in obese and non-obese women. METHODS: We evaluated the homeostasis model assessment of insulin resistance (HOMA-IR) and total anti-oxidant status (TAS) in a total of 111 healthy women between the ages of 32 and 68 years. RESULTS: In all of the study subjects, ferritin levels were positively correlated with age (r = 0.38, P < 0.001), body mass index (r = 0.24, P = 0.01), TAS (r = 0.38, P < 0.001) and HOMA-IR (r = 0.20, P = 0.04). In the subgroup analysis, ferritin levels were correlated with age (r = 0.39, P < 0.001) and TAS (r = 0.43, P < 0.001) in the non-obese group and with insulin (r = 0.50, P = 0.02) and HOMA-IR (r = 0.52, P = 0.01) levels in the obese group. On stepwise multiple linear regression analysis, ferritin was found to be independently associated with TAS (B = 177.16, P < 0.0001) in the non-obese group and independently associated with HOMA-IR (B = 30.36, P = 0.01) in the obese group. CONCLUSION: Our findings suggest ferritin is associated with IR in obese women and with anti-oxidative status in non-obese women. Further studies are warranted to elucidate the precise role of ferritin in obesity.
