Cholinergic anti-inflammatory pathway and its role in treatment of sepsis.
10.11817/j.issn.1672-7347.2020.180651
- Author:
Shuangfeng ZI
1
;
Jinghui LI
1
;
Lei LIU
1
;
Furong LIU
1
Author Information
1. Department of Critical Care Medicine, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Haikou 570208, China.
- Publication Type:Journal Article
- Keywords:
cholinergic anti-inflammatory pathway;
sepsis;
vagus nerve
- MeSH:
Acetylcholine;
Humans;
Inflammation;
Neuroimmunomodulation;
Sepsis;
Vagus Nerve Stimulation;
alpha7 Nicotinic Acetylcholine Receptor
- From:
Journal of Central South University(Medical Sciences)
2020;45(1):68-73
- CountryChina
- Language:English
-
Abstract:
The cholinergic anti-inflammatory pathway (CAP) is a neuro-immunomodulatory pathway,in which acetylcholine (ACh) released by the interaction of vagal nerves with α7 nicotinic acetylcholine receptor (α7nAChR),which prevents the synthesis and release of pro-inflammatory cytokines and ultimately regulates the local or systemic inflammatory response in a feedback manner. It has been shown that there are many possible effective treatments for sepsis, including vagus nerve stimulation by physical therapy, drugs such as acetylcholine receptor agonist and ultrasound therapy.
