Adipose-derived stem cells for the treatment of penile erectile dysfunction: An update.
- Author:
Yi WANG
1
;
Ya-Min WANG
1
;
Chen CHEN
1
;
Yi-Chun WANG
1
;
Ning-Hong SONG
1
Author Information
1. Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
- Publication Type:Journal Article
- Keywords:
adipose-derived stem cells;
erectile dysfunction;
penis
- MeSH:
Adipocytes;
transplantation;
Adipose Tissue;
cytology;
Animals;
Cell Differentiation;
Erectile Dysfunction;
surgery;
Humans;
Male;
Stem Cell Transplantation;
methods;
trends
- From:
National Journal of Andrology
2017;23(6):561-565
- CountryChina
- Language:Chinese
-
Abstract:
Adipose-derived stem cells (ADSCs) are pluripotent stem cells isolated from the adipose tissue and have the potential for self-renewal and multi-directional differentiation into neurogenic cells, smooth muscle cells, endothelial cells, and so on. Erectile dysfunction (ED) is a common male sexual dysfunction that has a negative impact on the lives of the patients and their partners. Current treatments of ED include surgery and medication, with oral 5-phosphodiesterase inhibitors as the first-line drugs. However, a small number of the patients are not sensitive to these therapies and cannot be improved or cured pathologically. So far, animal experiments and preclinical trials have confirmed the safety and efficacy of ADSCs, which act on ED though paracrine mechanisms. This review summarizes the advances in the recent 5 years in the studies of ADSCs for the treatment of ED.
