Circulating miR-152 helps early prediction of postoperative biochemical recurrence of prostate cancer.
- Author:
Jun-Feng CHEN
1
;
Yu-Feng LIAO
2
;
Jian-Bo MA
2
;
Qi-Feng MAO
2
;
Guang-Cheng JIA
3
;
Xue-Jun DONG
1
Author Information
1. Clinical Laboratory College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
2. Department of Clinical Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, China.
3. Department of Urology, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, China.
- Publication Type:Journal Article
- Keywords:
biochemical recurrence;
miR-152;
serum PSA;
prostate cancer
- MeSH:
Area Under Curve;
Bone Neoplasms;
secondary;
Case-Control Studies;
Humans;
Male;
MicroRNAs;
blood;
Neoplasm Grading;
Neoplasm Recurrence, Local;
blood;
Postoperative Period;
Prostatectomy;
Prostatic Neoplasms;
blood;
pathology;
surgery;
ROC Curve;
Sensitivity and Specificity
- From:
National Journal of Andrology
2017;23(7):603-608
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of circulating miR-152 in the early prediction of postoperative biochemical recurrence of prostate cancer.
METHODS:Sixty-six cases of prostate cancer were included in this study, 35 with and 31 without biochemical recurrence within two years postoperatively, and another 31 healthy individuals were enrolled as normal controls. The relative expression levels of circulating miR-152 in the serum of the subjects were detected by qRT-PCR, its value in the early diagnosis of postoperative biochemical recurrence of prostate cancer was assessed by ROC curve analysis, and the correlation of its expression level with the clinicopathological parameters of the patients were analyzed.
RESULTS:The expression of circulating miR-152 was significantly lower in the serum of the prostate cancer patients than in the normal controls (t = －5.212, P = 0.001), and so was it in the patients with than in those without postoperative biochemical recurrence (t = －5.727, P = 0.001). The ROC curve for the value of miR-152 in the early prediction of postoperative biochemical recurrence of prostate cancer showed the area under the curve (AUC) to be 0.906 (95% CI: 0.809－0.964), with a sensitivity of 91.4% and a specificity of 80.6%. The expression level of miR-152 was correlated with the Gleason score, clinical stage of prostate cancer, biochemical recurrence, and bone metastasis (P <0.05), decreasing with increased Gleason scores and elevated clinical stage of the malignancy. No correlation, however, was found between the miR-152 expression and the patients' age or preoperative PSA level (P >0.05).
CONCLUSIONS:The expression level of circulating miR-152 is significantly reduced in prostate cancer patients with biochemical recurrence after prostatectomy and could be a biomarker in the early prediction of postoperative biochemical recurrence of the malignancy.
