Qilan Capsules plus androgen-deprivation therapy for Qi-deficiency blood-stasis type of prostate cancer after castration.
- Author:
De-Gui CHANG
1
;
Xiang LI
2
;
Jian-Hua ZOU
3
;
Xu-Jun YU
1
;
Xiao-Fang PAN
1
;
Tian-Lang WU
4
;
Guang-Sen LI
4
;
Wen-Ying CHEN
4
;
Cheng CHEN
4
Author Information
1. Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610041, China.
2. Department of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
3. Department of Urology, Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China.
4. Department of Andrology, The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610072, China.
- Publication Type:Journal Article
- Keywords:
Qi-deficiency and blood stasis;
clinical efficacy;
prostate cancer;
Qilan Capsules
- MeSH:
Androgen Antagonists;
therapeutic use;
Capsules;
Double-Blind Method;
Drug Therapy, Combination;
methods;
Drugs, Chinese Herbal;
therapeutic use;
Humans;
Male;
Orchiectomy;
Prostate-Specific Antigen;
blood;
Prostatic Neoplasms;
blood;
blood supply;
surgery;
Qi;
Quality of Life;
Treatment Outcome
- From:
National Journal of Andrology
2017;23(7):646-651
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the synergistic effect of Qilan Capsules in the treatment of the patient with Qi-deficiency blood-stasis type of prostate cancer receiving androgen-deprivation therapy after castration.
METHODS:This randomized controlled double-blind study included 246 cases of Qi-deficiency blood-stasis type of prostate cancer after castration, which were randomly divided into an experiment and a control group of equal number to be treated with Qilan Capsules + androgen-deprivation and placebo + androgen-deprivation, respectively. After 6 months of treatment, we compared the International Prostate Symptoms Scores (IPSS), TCM Symptoms Scores (TCMSS), maximal urine flow rate (Qmax), and the level of serum prostate-specific antigen (PSA) between the two groups of patients.
RESULTS:Statistically significant differences were observed between the experiment and control groups in the syndrome classification-based efficacy (87.7% vs 67.9%, P <0.05) and total effectiveness rate (86.0% vs 71.6%, P <0.05). Compared with the baseline, the experiment group showed remarkable improvement after treatment in TCMSS (17.1±5.1 vs 8.3±4.0, P <0.05), IPSS (17.7±7.5 vs 11.4±4.6, P <0.05), and Qmax (［10.9±4.3］ ml/s vs ［14.7±3.7］ ml/s, P <0.05), and so did the control group (16.8±5.2 vs 11.5±5.2, 17.8±6.7 vs 14.6±5.8, and ［11.0±4.3］ ml/s vs ［12.0±4.1］ ml/s, P <0.05). The above three parameters were even more markedly improved in the former than in the latter group (P <0.05). However, there was no statistically significant difference between the two groups in the improvement of the PSA level after treatment (P >0.05).
CONCLUSIONS:Qilan Capsules can significantly enhance the effect of androgen-deprivation therapy in the treatment of Qi-deficiency blood-stasis type of prostate cancer after castration though cannot obviously improve the PSA level.
