Gene regulation of prostaglandin synthase and prostate diseases.
- Author:
Shuang-Shuang WU
1
;
Jian-Hui WU
1
;
Zu-Yue SUN
1
Author Information
1. Department of Pharmacology and Toxicology, Shanghai Institute of Planned Parenthood Research / National Evaluation Center for Toxicology of Fertility Regulation Drugs, Shanghai 200032, China.
- Publication Type:Journal Article
- Keywords:
benign prostatic hyperplasia;
gene regulation;
prostate cancer;
prostaglandin synthase
- MeSH:
Gene Expression Regulation;
Humans;
Male;
Prostaglandin-Endoperoxide Synthases;
genetics;
physiology;
Prostatic Hyperplasia;
enzymology;
genetics;
prevention & control;
Prostatic Neoplasms;
enzymology;
genetics;
prevention & control
- From:
National Journal of Andrology
2017;23(7):663-667
- CountryChina
- Language:Chinese
-
Abstract:
Prostaglandin synthase (PGS) can catalyze the production of various types of prostaglandins and regulate the expression levels of related substances. The regulation mechanisms of the PGS gene are closely related with the occurrence and development of prostate diseases. However, few studies are reported on the regulation mechanisms of PGS in prostatic diseases, such as benign prostatic hyperplasia (BPH) and prostate cancer (PCa), or on the relationship between PGS gene regulation and prostate diseases. This review aims to analyze their correlation and provide some ideas for the prevention and control of BPH and PCa by intervention of the prostaglandin synthase regulatory pathway.
