Expressions of interleukin-17 and interleukin-8 in the prostatic tissue of the patients with BPH or BPH with inflammation.
- Author:
Rui GAO
1
;
Qi-Xiang LIU
1
;
Hui-Liang ZHOU
2
;
Lin-Sheng CAO
1
;
Tao JIANG
1
;
Song-Xi TANG
2
;
Yi-Lang DING
2
Author Information
1. Department of Urology, The First Hospital Affiliated to Fujian Medical University, Fuzhou, Fujian 350005, China.
2. Department of Andrology, The First Hospital Affiliated to Fujian Medical University, Fuzhou, Fujian 350005, China.
- Publication Type:Journal Article
- Keywords:
benign prostatic hyperplasia;
inflammation;
interleukin-17;
interleukin-8
- MeSH:
Disease Progression;
Humans;
Inflammation;
metabolism;
Interleukin-17;
metabolism;
Interleukin-8;
metabolism;
Male;
Organ Size;
Prostate;
pathology;
Prostatic Hyperplasia;
complications;
metabolism;
Quality of Life;
RNA, Messenger;
metabolism;
Transurethral Resection of Prostate;
Treatment Outcome;
Urinary Retention;
diagnosis;
etiology
- From:
National Journal of Andrology
2017;23(8):697-702
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressions of interleukin-17 (IL-17) and interleukin-8 (IL-8) in benign prostatic hyperplasia (BPH) and BPH complicated with histological inflammation and their significance.
METHODS:According to the results of HE staining, we divided 60 cases of BPH treated by transurethral resection of the prostate (TURP) into a BPH group (n = 23) and a BPH with inflammation group (n = 37). We analyzed the clinical data of the patients and determined the mRNA and protein expressions of IL-17 and IL-8 by immunohistochemistry, real-time fluorescence quantitative PCR, and Western blot, respectively.
RESULTS:Compared with the BPH patients complicated with inflammation, the BPH group showed significantly lower International Prostate Symptom Score (IPSS) (29.1 ± 6.2 vs 21.6 ± 3.7), quality of life score (QoL) (5.4 ± 1.3 vs 4.4 ± 1.6), postvoid residual urine volume (RUV) (［198.6 ± 15.5］ vs ［98.2 ± 19.3］ ml), prostate volume (［69.2 ± 24.1］ vs ［49.8 ± 16.5］ ml), PSA level (［7.4 ± 1.9］ vs ［2.8 ± 0.8］ μg/L) and serum c-reactive protein content (CRP) (［5.1±2.0］ vs ［1.5±0.6］ mg/L), but a higher maximum urine flow rate (Qmax) (［4.7 ± 2.1］ vs ［8.2 ± 1.8］ ml/s) (all P<0.05). The former group had a significantly higher incidence rate of urinary retention than the latter (32.4% ［12/37］ vs 8.69% ［2/23］), mRNA expressions of IL-17 (0.303 ± 0.076 vs 0.042 ± 0.019) and IL-8 (0.536 ± 0.059 vs 0.108 ± 0.025), and protein expressions of IL-17 (0.88 ± 0.10 vs 0.34 ± 0.05) and IL-8 (1.07 ± 0.08 vs 0.43 ± 0.04) (all P<0.05).
CONCLUSIONS:The expressions of IL-17 and IL-8 are upregulated in the prostatic tissue of the BPH patients with inflammation, which may play a significant role in the development and progression of BPH.
