CatSper in sperm hyperactivation and male infertility: Advances in studies.
- Author:
Lin YANG
1
;
Hai-Xia CHEN
2
;
Xiao-Huan MU
2
;
Xiao-Qiang LIU
1
;
Xue-Ru SONG
2
;
Wen-Yan TIAN
2
Author Information
1. Department of Urology, Tianjin Medical University Second Hospital, Tianjin 300211, China.
2. Center of Reproductive Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.
- Publication Type:Journal Article
- Keywords:
CatSper channel;
Ca²⁺;
hyperactivation;
male infertility;
sperm
- MeSH:
Animals;
Calcium Channels;
chemistry;
physiology;
Humans;
Infertility, Male;
etiology;
Male;
Sperm Motility;
physiology;
Sperm Tail;
metabolism;
Sperm-Ovum Interactions;
physiology;
Spermatozoa;
physiology
- From:
National Journal of Andrology
2017;23(8):751-756
- CountryChina
- Language:Chinese
-
Abstract:
The CatSper channel is known as one of the most important Ca²⁺ channels on the cell membrane of mammalian sperm and plays a key role in the motility, hyperactivation and fertilization function of sperm. The CatSper protein, expressed exclusively in the principal piece of the sperm tail, is composed of CatSper1-4 and 5 auxiliary unitsβ,γ,δ and ε, and has an essential part in the functional and structural domains of Ca²⁺as well as in the spatiotemporal regulation of the P-Tyr protein, sperm hyperactivation, efficient sperm migration in the oviduct, egg penetration, and normal fertility. Recent studies show that functional deficiency of CatSper seriously affects sperm function,and the loss of any one of its 9 subunits may lead to male reproductive dysfunction. This paper outlines recent advances in the studies of the CatSperprotein, focusing on its expression, location, structure, and regulation,as well as itsinfluence on sperm hyperactivation and male reproduction.
