Toxicological characteristics of Ochratoxin A and its impact on male reproduction.
- Author:
Tian-Yu ZHANG
1
;
Yong ZHAO
1
;
Lan LI
1
;
Wei SHEN
1
Author Information
1. School of Animal Science and Technology / Research Institute of Reproductive Health, Qingdao Agricultural University, Qingdao, Shandong 266109, China.
- Publication Type:Journal Article
- Keywords:
ochratoxin A;
reproductive toxicology;
testis cancer;
toxicokinetics
- MeSH:
Animals;
Endocrine Disruptors;
pharmacokinetics;
toxicity;
Fertility;
drug effects;
Humans;
Male;
Ochratoxins;
pharmacokinetics;
toxicity;
Reproduction;
drug effects;
Spermatozoa;
drug effects;
Testicular Neoplasms;
chemically induced;
Testis;
drug effects
- From:
National Journal of Andrology
2017;23(8):757-762
- CountryChina
- Language:Chinese
-
Abstract:
Ochratoxin A (OTA) is found not only nephrotoxic, teratogenic, neurotoxic, and immunotoxic, but also reprotoxic for human and animals. In the recent decade, more attention has been paid to the impact of OTA on human reproduction and the studies of its underlying mechanisms. Many studies show that OTA affects the function of the reproductive system by acting as an endocrine disrupter and, as a testicular toxin, decreases sperm quality and even induces testis cancer. This review summarizes the toxicological characteristics and toxicokinetic process of OTA as well as recent progress in the studies of various toxic effects of OTA and their underlying mechanisms, hoping to call the attention from more people to the toxicity of OTA to male reproductive health.
