Trigger effect of hMG and hCG in the treatment of unexplainable non-obstructive azoospermia.
- Author:
Hao-Rui HU
1
;
Hong-Chuan NIE
2
;
Wei-Min YANG
1
;
Yuan SUN
1
;
Hui HUANG
1
;
Fang-Gang XIE
1
Author Information
1. Department of Assisted Reproduction, Maternity and Child Health Hospital of Guizhou Province / Maternity and Child Health Hospital of Guiyang, Guiyang, Guizhou 550002, China.
2. Human Sperm Bank, CITIC-Xiangya Hospital of Reproduction and Genetics, Changsha, Hunan 410007, China.
- Publication Type:Journal Article
- Keywords:
drug therapy;
percutaneous epididymal sperm aspiration;
testicular sperm extraction;
non-obstructive azoospermia
- MeSH:
Azoospermia;
drug therapy;
Chorionic Gonadotropin;
therapeutic use;
Drug Administration Schedule;
Epididymis;
Female;
Fertility Agents, Male;
therapeutic use;
Humans;
Injections, Intramuscular;
Male;
Menotropins;
therapeutic use;
Pregnancy;
Pregnancy Rate;
Reproductive Techniques, Assisted;
Retrospective Studies;
Sperm Retrieval;
statistics & numerical data;
Spermatozoa;
Testis
- From:
National Journal of Andrology
2017;23(9):813-816
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether the trigger effect of human menopausal gonadotropins (hMG) and human chorionic gonadotropins (hCG) attributes to the treatment of unexplainable non-obstructive azoospermia (NOA).
METHODS:We retrospectively analyzed the clinical data about 282 cases of unexplainable NOA treated in the Maternity and Child Health Hospital of Guizhou Province from January 2010 to May 2017. All the patients underwent trigger treatment by intramuscular injection of hMG at 75 IU 3 times a week for 2 weeks, followed by hCG at 2 000 IU twice a week for another 2 weeks, and meanwhile took vitamin E, Levocarnitine and Tamoxifen as an adjunctive therapy. The treatment lasted 3－12 months.
RESULTS:Fifty-eight of the 255 patients that completed the treatment were found with sperm in the semen after treatment, all with severe oligoasthenospermia. Forty-seven of the 58 cases received assisted reproductive technology (ART), of which 18 achieved clinical pregnancy. Semen centrifugation revealed no sperm in the other cases, of which 6 were found with epididymal sperm at epididymal and testicular biopsy after treatment and 3 of them achieved clinical pregnancy after ART. Sperm was found in the semen or at epididymal or testicular biopsy in 64 of the patients after treatment, with an effectiveness rate of 25.1%.
CONCLUSIONS:Trigger treatment by injection of hMG and hCG combined with adjunctive oral medication has a certain effect on unexplainable NOA.
