Association of abnormal length of Y chromosome with semen quality and outcome of assisted reproductive technology in humans.
- Author:
Bin-Ye LI
1
;
Yong-Tian ZHANG
1
;
Xiang-Hui ZENG
1
;
Jin-Chun LÜ
1
Author Information
1. Center of Reproductive Medicine, Qinghai Provincial People's Hospital, Xining, Qinghai 810007, China.
- Publication Type:Journal Article
- Keywords:
outcome of assisted reproductive technology;
semen parameters;
long and short Y chromosomes
- MeSH:
Asthenozoospermia;
genetics;
Azoospermia;
genetics;
Chi-Square Distribution;
Chromosomes, Human, Y;
Female;
Humans;
Karyotype;
Karyotyping;
Male;
Pregnancy;
Pregnancy Rate;
Reproductive Techniques, Assisted;
Semen;
Semen Analysis;
standards;
Sex Chromosome Aberrations;
Spermatogenesis;
Treatment Outcome
- From:
National Journal of Andrology
2017;23(9):817-820
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of the abnormal length of human Y chromosome with semen quality and the outcome of assisted reproductive technology (ART).
METHODS:Based on the karyotype, we assigned the patients undergoing ART to a normal control, a long Y chromosome (Y>18), and a short Y chromosome group (Y<22). We compared the semen parameters and numbers of embryos and high-quality embryos among the three groups of patients and performed statistical analysis of the obtained data using Chi-square distribution and t-test.
RESULTS:Compared with the control, the Y>18 group showed a significantly lower incidence rate of asthenozoospermia (31.03% vs 8.33%, P <0.05) and a larger number of high-quality embryos (5.46 ± 4.54 vs 7.40 ± 5.49, P<0.05). Both the incidence rate of azoospermia and number of total embryos were remarkably lower in the control than in the Y<22 group (1.87% vs 16.47%, P <0.05; 8.60 ± 7.03 vs 10.00 ± 6.58, P<0.05). No statistically significant differences were found in the pregnancy rate between the Y>18 and Y<22 groups (P>0.05).
CONCLUSIONS:Short Y chromosome may affect spermatogenesis, but the length of Y chromosome does not negatively influence the outcome of ART.
