Efficacy and safety of traditional Chinese medicine combined with sildenafil in the treatment of ED in Chinese men： A real-world study.
- Author:
Jun GUO
1
;
De-Gui CHANG
2
;
Lei CHEN
3
;
Bin OU-YANG
4
;
Rui ZHANG
5
;
Qiang GENG
4
;
Chao YU
3
;
Fu WANG
1
;
Qing-He GAO
1
;
Guo-Jin YU
1
;
Xiu-Ju ZHANG
1
Author Information
1. Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.
2. Department of Urology， The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China.
3. Department of Urology， Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
4. Department of Andrology, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300073, China.
5. Department of Andrology, The Second Hospital Affiliated to Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China.
- Publication Type:Journal Article
- Keywords:
erectile dysfunction;
safety;
therapeutic effect evaluation;
real-world study
- MeSH:
Aged;
Asian Continental Ancestry Group;
Coitus;
Drug Therapy, Combination;
methods;
Drugs, Chinese Herbal;
therapeutic use;
Erectile Dysfunction;
drug therapy;
etiology;
Humans;
Male;
Medicine, Chinese Traditional;
Penile Erection;
drug effects;
physiology;
Sildenafil Citrate;
therapeutic use;
Treatment Outcome;
Yang Deficiency;
complications;
Yin Deficiency;
complications
- From:
National Journal of Andrology
2017;23(10):917-921
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To make a real-world study on the efficacy and safety of traditional Chinese medicine (TCM) combined with sildenafil in the treatment of erectile dysfunction (ED) that failed to respond to TCM medication.
METHODS:This study included 1 038 ED patients with the International Index of Erectile Function-5 (IIEF-5) scores ≤21 and improvement <30% after 4 weeks of TCM medication, differentially diagnosed with kidney-yang or kidney-yin deficiency syndrome. We administered TCM combined with sildenafil (Viagra, Pfizer Pharmaceutical Co., Ltd) at 100 mg 1 hour before sexual intercourse. After 2 and 4 weeks of medication, we recorded the scores in IIEF-5, erection hardness, Sexual Encounter Profile question 2 (SEP-2: whether vaginal penetration is successful), SEP-3 (whether sexual intercourse is successful), and TCM Syndromes Scale as well as the indexes of routine blood, urine, liver function, and renal function of the patients, and compared them with those obtained before treatment.
RESULTS:No serious adverse reactions were observed in any of the patients. Compared with the baseline, the patients achieved significantly increased IIEF-5 scores after 2 and 4 weeks of medication (15.01 ± 2.25 vs 16.96 ± 2.55 and 19.41 ± 2.82, P <0.05), penileelectionhardness remarkably improved at 4 weeks (3.36% vs 44.58%, P<0.05), and the positive answers to SEP-2 and SEP-3 both markedly increased at 2 (38.11% vs 90.49%, P<0.05; 22.01% vs 63.77% , P<0.05) and 4 weeks (38.11% vs 96.95% , P<0.05; 22.01% vs 89.73%, P<0.05).
CONCLUSIONS:TCM combined with sildenafil is safe and effective in the treatment of ED in Chinese men, which can significantly improve the IIEF-5 score and erection hardness of the patients.
