Correlation of serum zinc alpha 2 glycoprotein with blood lipid and reproductive hormone levels in men.
- Author:
Chao-Ju YANG
1
;
Rui-Yu HAN
2
;
Shu-Song WANG
2
Author Information
1. Department of Clinical Laboratory, Hebei Province People's Hospital, Shijiazhuang, Hebei 050051, China.
2. Hebei Research Institute of Family Planning Science and Technology / Key Laboratory of Family Planning and Healthy Birth, National Health and Family Planning Commission, Shijiazhuang, Hebei 050071, China.
- Publication Type:Journal Article
- Keywords:
testosterone;
zinc alpha 2 glycoprotein;
male
- MeSH:
Adult;
Age Factors;
Aged;
Blood Glucose;
analysis;
Body Mass Index;
Follicle Stimulating Hormone;
Gonadal Steroid Hormones;
blood;
Humans;
Lipids;
blood;
Male;
Middle Aged;
Obesity, Abdominal;
etiology;
Reproduction;
Seminal Plasma Proteins;
blood;
Triglycerides;
blood
- From:
National Journal of Andrology
2017;23(11):997-1001
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the changes of the serum zinc alpha 2 glycoprotein (ZAG) level in men and its relationship with blood lipid male reproductive hormones.
METHODS:We enrolled 297 men aged 25- 65 years in this study, 152 with hyperlipemia (HL) and the other 145 with normal blood lipid (normal control). We divided them into four age groups (25-35 yr, 36-45 yr, 46-55 yr, and 56-65 yr) and three tertile groups (Q1, Q2, and Q3) according to the tertiles of the serum ZAG level, and examined their blood lipid, blood glucose, serum ZAG, and reproductive hormones.
RESULTS:The serum ZAG level was decreased gradually with the increase of age in both the HL patients and normal controls, significantly in the 36-45 and 56-65 yr age groups (P <0.05), and markedly lower in the HL than in the control men in the 25-35 and 36-45 yr groups (P <0.05). The levels of follicle-stimulating hormone (FSH) and total testosterone (TT) changed significantly with the ZAG level. The level of serum ZAG was correlated negatively with age (r = -0.58, P<0.05), waist circumference (r = -0.21, P <0.05), body mass index (BMI) (r = -0.22, P <0.05), fasting blood glucose (r = -0.16, P <0.05) , and triglyceride (TG) (r = -0.27, P <0.05) but positively with TT (r = 0.36, P <0.05). Age, BMI and TG were independent factors influencing the serum ZAG level.
CONCLUSIONS:The serum ZAG level is decreased with the increase of age and associated with lipid metabolism, abdominal obesity, and reproductive hormone levels in males.