Idiopathic teratozoospermia is not correlated with c.144delC polymorphism in the AURKC gene in Sichuan.
- Author:
Xue-Mei MU
1
;
Fang-Ying CUI
1
;
Zhuo ZHANG
1
;
Xian-Ping DING
1
Author Information
1. Research Institute of Medical Genetics, School of Life Science, Sichuan University, Chengdu, Sichuan 610064, China.
- Publication Type:Journal Article
- Keywords:
AURKC;
mutation;
polymorphism;
teratozoospermia;
male infertility
- MeSH:
Aurora Kinase C;
genetics;
Humans;
Male;
Mutation;
genetics;
Polymorphism, Genetic;
Spermatozoa;
Teratozoospermia;
genetics
- From:
National Journal of Andrology
2017;23(12):1069-1074
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of a very common mutation of c.144delC in the aurora kinase C (AURKC) gene with idiopathic teratozoospermia in Chinese infertile men in Sichuan.
METHODS:Using polymerase chain reaction (PCR) and next-generation sequencing, we analyzed the correlation between c.144delC polymorphism of the AURKC gene and male infertility in 98 idiopathic teratozoospermia patients in comparison with 162 normal fertile men.
RESULTS:Neither c.144delC mutation nor other meaningful mutations were detected in the AURKC gene in the 98 idiopathic teratozoospermia patients or the 162 normal controls.
CONCLUSIONS:Teratozoospermia is not correlated with c.144delC mutation in the AURKC gene in the men of the Sichuan area. Therefore, large-scale genotyping of the AURKC gene may not be necessary clinically among Chinese patients with idiopathic teratozoospermia.
