Microdissection testicular sperm extraction for patients with nonmosaic Klinefelter syndrome: A report of 143 cases.
- Author:
Jia-Ming MAO
1
;
Lian-Ming ZHAO
2
;
Kai HONG
2
;
Wen-Hao TANG
2
;
De-Feng LIU
3
;
Hao-Cheng LIN
2
;
Han WU
2
;
Hai-Tao ZHANG
4
;
Hong-Liang ZHANG
1
;
Yu-Zhuo YANG
1
;
Ya-Peng WANG
1
;
Ying LIAN
1
;
Hui JIANG
2
;
Lu-Lin MA
2
;
Jie QIAO
1
Author Information
- Publication Type:Journal Article
- Keywords: Klinefelter syndrome; non-obstructive azoospermia; pregnancy rate; sperm retrieval; microdissection testicular sperm extraction
- MeSH: Female; Humans; Klinefelter Syndrome; Male; Microdissection; Pregnancy; Pregnancy Rate; Sperm Injections, Intracytoplasmic; Sperm Retrieval; Spermatozoa; Testis
- From: National Journal of Andrology 2017;23(12):1075-1079
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical application and outcomes of microdissection testicular sperm extraction (micro-TESE) in patients with nonmosaic Klinefelter syndrome (KS).
METHODS:A total of 143 nonmosaic KS patients underwent micro-TESE in the Center of Reproductive Medicine of Peking University Third Hospital between July 2012 and August 2016. We analyzed their clinical and follow-up data and evaluated the outcomes.
RESULTS:Spermatozoa were successfully retrieved from the testicular tissue in 44.76% (64/143) of the patients, 84.4% (54/64) by unilateral and 15.6% (10/64) by bilateral micro-TESE. Seventy-five of the KS patients were followed up in the years of 2014 and 2015. Of the 34 patients with successful sperm retrieval, 73.52% (25/34) achieved clinical pregnancy and 8 boys and 8 girls were already born in 14 of the 25 cases.
CONCLUSIONS:The micro-TESE is a useful method for sperm retrieval in nonmosaic KS patients, with high rates of sperm retrieval, clinical pregnancy, and birth of biological offspring.
