Relationship between the FSHR Thr307Ala-Asn680Ser gene polymorphism and male infertility: A meta-analysis.
- Author:
Jun LUO
1
;
Lin WANG
2
;
Heng-Chuan SHI
3
;
Qing-Qi ZENG
1
;
Qiu-Yue WU
4
;
Wei-Wei LI
4
Author Information
1. Central Laboratory, Jiangsu Health Vocational College, Nanjing, Jiangsu 210029, China.
2. Department of Clinical Laboratory, The Second Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210002, China.
3. Department of Clinical Laboratory, Jiangsu Provincial Agency Hospital, Nanjing, Jiangsu 210002, China.
4. PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
- Publication Type:Journal Article
- Keywords:
Asn680Ser;
FHS receptor;
Thr307Ala;
gene polymorphism;
meta-analysis;
male infertility
- MeSH:
Case-Control Studies;
Follicle Stimulating Hormone, Human;
genetics;
Homozygote;
Humans;
Infertility, Male;
genetics;
Male;
Polymorphism, Genetic;
Risk Factors
- From:
National Journal of Andrology
2017;23(12):1121-1126
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the association of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility.
METHODS:We searched Pubmed, EMBASE, Web of Science, CNKI, and WANFANG databases for literature on the correlation of the FSHR Thr307Ala-Asn680Ser gene polymorphism with male infertility published from 2005 to the present time. According to the inclusion criteria, we included 12 epidemiological case-control studies and subjected them to a comprehensive analysis with the Stata11.0 software.
RESULTS:A total of 2 893 male infertility patients and 3 312 controls were involved in the 12 studies. The Thr307Ala (rs6165) gene polymorphism was shown to be a risk factor for male infertility among the three comparison models (homozygous comparison model, hybrid comparison model and dominant comparison model), with the pooled odds ratios (OR) of 1.26 (95% CI: 1.03－1.54, P = 0.023), 1.18 (95% CI: 1.03－1.36, P = 0.018), and 1.20 (95% CI: 1.05－1.37, P = 0.006), respectively. And the Asn680Ser(rs6166) polymorphism was a risk factor for male infertility in the homozygous comparison and recessive comparison models, with the pooled ORs of 1.24, (95% CI: 1.05－1.45, P = 0.009) and 1.20 (95% CI: 1.04－1.39, P = 0.013), respectively. Layered meta-analysis showed that in the homozygous comparison model, the Thr307Ala-Asn680Ser polymorphism is a risk factor for male infertility in the white population, with the OR of 1.37 (95% CI: 1.03－1.82, P = 0.003) and 1.21 (95% CI: 1.00－1.47, P = 0.048), respectively.
CONCLUSIONS:In the homozygous model (GG vs AA), the FSHRThr307Ala-Asn680Ser gene polymorphism might be a protective factor against male infertility.
