Vasectomy has no obvious longterm influence on the levels of serum androgens in aging males.
- Author:
Yong-Jun SHI
1
;
Na YU
2
;
Shi-Min XIONG
1
;
Fang-Wei LIU
1
;
Pei-Pei WANG
3
;
Cheng-Liang XIONG
4
;
Yuan-Zhong ZHOU
1
;
Xu-Bo SHEN
5
Author Information
1. Department of Toxicology, School of Public Health, Zunyi Medical College, Zunyi, Guizhou 563099, China.
2. School of Public Health, Guangdong Medical University, Dongguan, Guangdong 523808, China.
3. Department of Oncology, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China.
4. Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
5. Department of Preventive Medicine, School of Public Health, Zunyi Medical College, Zunyi, Guizhou 563099, China.
- Publication Type:Journal Article
- Keywords:
long term influence;
aging male;
androgen;
vasectomy
- MeSH:
Adult;
Aged;
Aging;
blood;
Androgens;
blood;
Humans;
Luteinizing Hormone;
blood;
Male;
Middle Aged;
Physical Examination;
Sex Hormone-Binding Globulin;
analysis;
Surveys and Questionnaires;
Testosterone;
blood;
Time Factors;
Vasectomy
- From:
National Journal of Andrology
2017;23(2):125-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the longterm influence of vasectomy on the levels of serum androgens in aging males.
METHODS:Using stratified random sampling, we conducted a questionnaire survey and physical examinations among 437 adult males aged ≥40 years, 232 with and 205 without the history of vasectomy. In addition, we measured the levels of serum total testosterone (TT), sexhormone binding globulin (SHBG), calculated free testosterone (cFT), testosterone secreting index (TSI), free testosterone index (FTI), and luteinizing hormone (LH).
RESULTS:Compared with the nonvasectomy group, the vasectomy group showed significantly increased levels of serum TT (［16.01±5.41］ vs ［17.39±6.57］ nmol/L), SHBG (［58.91±36.89］ vs ［70.28±40.90］ nmol/L), and LH (［8.86±6.49］ vs ［10.85±11.73］ IU/L) (all P< 0.05) and a decreased level of FTI (0.33±0.15 vs 0.30±0.12, P< 0.05). There were no statistically significant differences between the nonvasectomy and vasectomy groups in cFT (［0.24±0.07］ vs ［0.23±0.09］ nmol/L) or TSI (［2.42±1.34］ vs ［2.46±1.51］ nmol/IU) (both P>0.05), nor after adjustment for relevant factors in TT (β: 1.015, 95% CI: －0.180－2.210), SHBG (β: 5.118, 95% CI: －2.069－12.305), cFT (β: 0.003, 95% CI: －0.011－0.018), FTI (β: －0.012, 95% CI: －0.035－0.011), TSI (β: 0.138, 95% CI: －0.131－0.407), and LH (β: 1.011, 95% CI: －0.811－2.834) (all P>0.05).
CONCLUSIONS:Vasectomy has no obvious longterm influence on the levels of serum androgens in aging males.
