Dynamic changes of reproductive hormone levels and related factors in old and middleaged men in health examination.
- Author:
Jian CHEN
1
;
Qin-Shi PAN
1
;
Yu-Min WANG
1
;
Xing-Xing ZHOU
1
Author Information
1. Center of Medical Laboratory, The First Hospital Affiliated to Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
- Publication Type:Journal Article
- Keywords:
age;
male;
reproductive hormone;
serum lipid
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Aging;
blood;
Estradiol;
blood;
Follicle Stimulating Hormone;
blood;
Humans;
Lipids;
blood;
Luteinizing Hormone;
blood;
Male;
Middle Aged;
Progesterone;
blood;
Prolactin;
blood;
Reproduction;
Statistics, Nonparametric;
Testosterone;
blood
- From:
National Journal of Andrology
2017;23(2):131-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the dynamic changes of serum reproductive hormone levels in old and middleaged males in health examination and their correlation with age and lipid profile.
METHODS:This study included 4 333 men in health examination from January 2011 to December 2014. The men were aged from 40 to 85 years old and divided into seven fiveyearspan age groups. We determined the levels of serum testosterone (T), luteinizing hormone (LH), folliclestimulating hormone (FSH), estradiol (E2), progesterone (P), prolactin (PRL), total cholesterol (TC), triglyceride (TG), lowdensity lipoprotein cholesterol (LDLC), highdensity lipoprotein cholesterol (HDLC), and the testosterone secretion index (TSI = T/LH). We analyzed the obtained data using SPSS Pram, KruskalWallis H test, MannWhitney U test, exponential regression, and Spearman correlation analysis.
RESULTS:Statistically significant differences were found in LH, FSH, E2 and TSI among the seven age groups (P< 0.05). The levels of serum LH, FSH and E2 were significantly higher (P< 0.05) while TSI remarkably lower (P< 0.05) in the ≥70 yr group than in the other six groups. The serum T and E2 levels and TSI were markedly lower in the 40－44, 45－49 and 50－54 yr groups in 2014 than in the other three years (P< 0.05), and so were the levels of serum T and TSI in the 55－59 yr group (P< 0.05). The levels of serum LH, FSH and E2 were correlated positively while those of P, PRL and TSI negatively with age. The serum T level was correlated positively with HDLC but negatively with TC, TG and LDLC. The levels of serum LH, FSH and E2 showed a yearly average increase of 1.9%, 2.7% and 0.5%, respectively, while TSI an annual mean decline of 2.0% in the 40－85 yr group.
CONCLUSIONS:LH, FSH and E2 were increased while TSI decreased with age in the >40 years old males. T and TSI were reduced in the 40－59 years old men from 2011 to 2014, and so was E2 in the 40－54 yr group. Lowlevel testosterone is closely related to dyslipidemia.
