Single nucleotide polymorphism of the TP53 gene is not correlated with male infertility.
- Author:
Meng-Xia NI
1
;
Hui-Jie ZHI
1
;
Shuai-Mei LIU
1
;
Pei-Ran ZHU
2
;
Jing ZHANG
1
;
Qiu-Yue WU
2
;
Wei-Jun JIANG
2
;
Mao-Mao YU
2
;
Wei-Wei LI
2
;
Jin CAO
2
;
Hao-Qin XU
3
;
Xin-Yi XIA
2
;
Xiao-Feng XU
1
;
Liang SHI
4
Author Information
1. School of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu 210023, China.
2. PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu, 210002, China.
3. Institute of Family Planning Science of Jiangsu Provice, Nanjing, Jiangsu 210029, China.
4. Department of Andrology, Drum Tower Hospital, Nanjing Medical University School of Medicine, Nanjing, Jiangsu 210008, China.
- Publication Type:Journal Article
- Keywords:
male infertility;
rs1042522;
single nucleotide polymorphism;
tumor protein p53 (TP53) gene
- MeSH:
Case-Control Studies;
Follicle Stimulating Hormone;
blood;
Gene Frequency;
Genes, p53;
genetics;
Genetic Predisposition to Disease;
Genotype;
Humans;
Infertility, Male;
blood;
genetics;
Logistic Models;
Male;
Polymorphism, Single Nucleotide;
Sperm Count;
Sperm Motility;
Testosterone;
analogs & derivatives;
blood
- From:
National Journal of Andrology
2017;23(2):142-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation of the single nucleotide polymorphism (SNP) rs1042522 of the tumor protein p53 (TP53) gene with the risk of male infertility.
METHODS:This casecontrol study included 380 male patients with idiopathic infertility and 398 normal fertile men as controls from the Nanjing area. We genotyped the SNP rs1042522 of the TP53 gene by Sequence Mass Array and analyzed the correlation of the SNP with male infertility using the logistic regression model.
RESULTS:Compared with the normal controls, the patients with idiopathic infertility showed significantly decreased sperm concentration (［77.34±49.24］ vs ［13.13±24.96］ ×106/ml), percentage of progressively motile sperm (［42.55±9.57］ vs ［10.38±5.57］%), serum testosterone level (［14.07±5.36］ vs ［11.89±4.50］ nmol/L), and folliclestimulating hormone level (［16.80±18.20］ vs ［4.55±7.17］ U/L) (P < 0.05) but no statistically significant differences in other parameters. No correlation was observed between the SNP frequencies and male infertility and similar results were found in the subgroups of the cases.
CONCLUSIONS:SNP rs1042522 of the TP53 gene is not significantly correlated with the risk of male infertility.
