Ningmitai Capsules combined with doxycycline hydrochloride for Ureaplasma urealyticumpositive chronic prostatitis.
- Author:
Li-Hua LI
1
;
Xun-Bin HUANG
1
;
Hui-Ping ZHANG
1
;
Dun-Zhen XIAO
1
;
Jing-Song CHAI
1
;
Zhen YE
1
Author Information
1. Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China..
- Publication Type:Journal Article
- Keywords:
Ningmitai Capsules;
Ureaplasma urealyticum;
chronic prostatitis;
doxycycline hydrochloride;
drug combination
- MeSH:
Anti-Bacterial Agents;
therapeutic use;
Capsules;
Chemotherapy, Adjuvant;
Chronic Disease;
Doxycycline;
therapeutic use;
Drugs, Chinese Herbal;
therapeutic use;
Humans;
Male;
Prostatitis;
drug therapy;
microbiology;
Ureaplasma Infections;
drug therapy;
microbiology;
Ureaplasma urealyticum
- From:
National Journal of Andrology
2017;23(2):169-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of Ningmitai Capsules (NMT) combined with doxycycline hydrochloride (DH) on chronic prostatitis induced by Ureaplasma urealyticum (Uu).
METHODS:This randomized controlled trial included 240 male patients with Uupositive chronic prostatitis, treated orally with NMT at 4 capsules tid (n= 35), DH at 100 mg bid (n = 78), and NMT+DH at the corresponding doses (n = 127), respectively, all for 2 successive weeks. At 1 week after drug withdrawl, we conducted routine urine analysis, EPS examination, and drug sensitivity test of the cultured Uu.
RESULTS:The positivetonegative rate of Uu was significantly higher in the NMT+DH group than in the NMT and DH groups (89.0% ［113/127］ vs 54.3% ［19/35］ and 71.8% ［56/78］, P< 0.05), so were the cure rate (25.2% vs 20.0% and 20.5%, P< 0.05) and total effectiveness rate (89.0% vs 54.3% and 71.8%, P< 0.05).
CONCLUSIONS:The combination of Ningmitai Capsules and doxycycline hydrochloride is more effective than either Ningmitai Capsules or doxycycline hydrochloride used alone in the treatment of Uupositive chronic prostatitis.
