Genetic genes associated with oligospermia, asthenospermia and teratospermia: Advances in studies.
- Author:
Ke GAO
1
;
Zhi-Qiang WANG
2
;
Xing-Chen LIU
1
;
Zhi-Long DONG
1
;
Wen-Sheng SHAN
2
Author Information
1. Research Institute of Urology / Key Laboratory for Urinary System Diseases of Gansu Province / Center of Clinical Medicine for Urinary System Diseases of Gansu Province, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China.
2. Department of Andrology, Maternity and Child Health Hospital of Gansu Province, Lanzhou, Gansu 730050, China.
- Publication Type:Journal Article
- Keywords:
asthenospermia;
gene;
oligospermia;
teratozoospermia
- MeSH:
Asthenozoospermia;
genetics;
Aurora Kinase C;
genetics;
Calcium Channels;
genetics;
Cytochrome P-450 CYP1A1;
genetics;
Cytoplasmic Dyneins;
DNA (Cytosine-5-)-Methyltransferases;
genetics;
Dyneins;
genetics;
Glutathione Transferase;
genetics;
Glycoproteins;
genetics;
Humans;
Male;
Membrane Proteins;
genetics;
Microtubule Proteins;
genetics;
Oligospermia;
genetics;
Spermatogenesis;
genetics;
Teratozoospermia;
genetics
- From:
National Journal of Andrology
2017;23(4):367-371
- CountryChina
- Language:Chinese
-
Abstract:
Approximately 2,300 genes are found to be associated with spermiogenesis and their expressions play important roles in the regulation of spermiogenesis. In recent years, more and more attention has been focused on the studies of the genes associated with oligospermia, asthenospermia and teratospermia and their molecular mechanisms. Some genes, such as GSTM1, DNMT3L, and CYP1A1, have been shown to be potentially associated with oligospermia; some, such as CATSPER1, CRISP2, SEPT4, TCTE3, TEKT4, and DNAH1, with asthenospermia; and still others, such as DPY19L2 and AURKC, with teratospermia. These findings have provided a molecular basis for the studies of the pathogenesis of oligospermia, asthenospermia and teratospermia, as well as a new approach to the exploration of new diagnostic and therapeutic techniques.
