Expressions of glutathione S-transferase P1 and 4- hydroxynonenal and the progression of prostate cancer.
- Author:
Xu SONG
1
;
Rong WANG
1
;
Feng XIAO
1
;
Sheng-Xi ZHANG
1
;
Min GONG
1
;
Xiu-Ling WANG
1
;
Yun ZHANG
1
;
Jin-Yang HUANG
1
Author Information
1. Department of Urology, The Seventh People's Hospital of Shanghai University of Chinese Medicine, Shanghai 200137, China.
- Publication Type:Journal Article
- Keywords:
4-hydroxynonenal;
glutathione S-transferase;
immunohistochemistry;
prostate cancer
- MeSH:
Aldehydes;
metabolism;
Disease Progression;
Glutathione S-Transferase pi;
metabolism;
Humans;
Immunohistochemistry;
Male;
Neoplasm Grading;
Neoplasm Proteins;
metabolism;
Prostatic Hyperplasia;
metabolism;
pathology;
Prostatic Neoplasms;
metabolism;
pathology
- From:
National Journal of Andrology
2017;23(5):412-416
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressions of glutathione S-transferase (GSTP1) and tetra-hydroxynonenal (4-HNE) in prostate cancer (PCa) and their clinical significance.
METHODS:We determined the expressions of GSTP1 and 4-HNE in 40 patients with PCa and another 42 with benign prostatic hyperplasia (BPH) by immunohistochemistry and analyzed their relationship with Gleason grades.
RESULTS:The expression rate of GSTP1 was 92.9% in the BPH tissue, and those in the highly, moderately, and lowly differentiated PCa tissues were 58.3%, 20.0%, and 16.7%, respectively, significantly higher in the BPH than in the PCa group (P <0.01). However, the positive rate of 4-HNE was only 5.0% in the BPH tissue, markedly lower than 91.6%, 100.0%, and 100.0% in the highly, moderately, and lowly differentiated PCa tissues (P <0.01). There was a negative correlation between the expression of GSTP1 and that of 4-HNE in the PCa tissue (r = －2.73, P <0.01).
CONCLUSIONS:Expression deletion of GSTP1 and high expression of 4-HNE may play an important role in the progression of prostate cancer.
