Hepatitis B virus infection increases the incidence of immune infertility in males.
- Author:
Hua-Feng BEI
1
;
Ren-Xiong WEI
1
;
Xiao-Dan CAO
1
;
Xiao-Xia ZHANG
1
;
Jun ZHOU
1
Author Information
1. Laboratory of Andrology, Ningbo Hospital of Traditional Chinese Medicine, Ningbo, Zhejiang 315012, China.
- Publication Type:Journal Article
- MeSH:
Hepatitis B;
complications;
immunology;
Hepatitis B Surface Antigens;
analysis;
Hepatitis B virus;
immunology;
Humans;
Incidence;
Infertility, Male;
epidemiology;
virology;
Male;
Semen;
Semen Analysis;
Sperm Count
- From:
National Journal of Andrology
2017;23(5):431-435
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between hepatitis B virus (HBV) infection and the incidence of male immune infertility.
METHODS:Based on the levels of serum HBsAg, 3 124 infertile men were classified into an HBV-positive and an HBV-negative group and, according to the results of IBT tests, those with immune infertility were further divided into an HBV-positive and an HBV-negative group. Statistical analyses were made on the incidence rate of immune infertility and seminal parameters in the immune infertility patients of the HBV-positive and HBV-negative groups, the correlation of the number of HBV DNA copies in the serum with that in the seminal plasma of the HBV-positive patients, the association of the numbers of HBV DNA copies in the serum and seminal plasma with semen parameters, and the relationship of the number of HBV DNA copies in the seminal plasma with the incidence of immune infertility. Sperm concentration and the percentage of progressively motile sperm (PMS) were measured by computer-aided sperm analysis, sperm morphology determined by Diff-Quik staining, the level of HBsAg detected by ELISA, and the numbers of HBV DNA copies in the serum and seminal plasma calculated by RT-PCR.
RESULTS:The incidence rate of immune infertility was significantly higher in the HBV-positive than in the HBV-negative group (20.3 vs 3.3%, χ2 = 187.5, P <0.01), and the percentage of morphologically normal sperm (MNS) was markedly lower in the HBV-positive than in the HBV-negative infertility patients (［3.9 ± 1.7］ vs ［6.3 ± 2.2］%, P <0.05), but no statistically significant differences were observed between the two groups of infertile males in the semen volume, sperm concentration, or PMS (P >0.05). The number of HBV DNA copies in the serum was positively correlated with that in the seminal plasma (rs = 0.86, P <0.01) while both the number of HBV DNA copies in the serum and that in the seminal plasma were negatively correlated with PMS (r = －0.233 and －0.465, P <0.01) and MNS (r = －0.250 and －0.508, P <0.01). The incidence rate of immune infertility showed no statistically significant differences among the groups with different numbers of HBV DNA copies in the seminal plasma (P >0.05).
CONCLUSIONS:HBV infection can increase the incidence rate of immune infertility in men and is correlated with the low quality of sperm.
