Correlation of serum anti-Müllerian hormone with semen parameters.
- Author:
Long-Ping PENG
1
;
Yong SHAO
2
;
Cen-Cen WANG
2
;
Zhi-Chuan ZOU
2
;
Tao SHEN
2
;
Li CHEN
2
;
Bing YAO
1
Author Information
1. Center of Reproductive Medicine, Jinling Hospital Affiliated to Southern Medical University, Nanjing, Jiangsu 210002, China.
2. Center of Reproductive Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
- Publication Type:Journal Article
- MeSH:
Anti-Mullerian Hormone;
blood;
Azoospermia;
blood;
Biomarkers;
blood;
Follicle Stimulating Hormone;
blood;
Humans;
Inhibins;
blood;
Male;
Oligospermia;
blood;
Semen;
Semen Analysis;
Sertoli Cells;
physiology;
Sperm Count;
Sperm Motility;
Spermatogenesis;
Spermatozoa;
Testosterone;
blood
- From:
National Journal of Andrology
2017;23(6):531-535
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between the serum anti-Müllerian hormone (AMH) level and semen parameters.
METHODS:We collected the data about 726 outpatients at the Male Infertility Clinic of Jinling Hospital from September 2015 to November 2016, including 72 with non-obstructive azoospermia, 123 with oligospermia, and 531 with normal sperm concentration. We obtained the semen volume, total sperm count, sperm concentration, sperm motility, the percentages of progressively motile sperm (PMS) and morphologically normal sperm (MNS), and the levels of serum AMH, inhibin B (INH-B), total testosterone (TT) and follicle - stimulating hormone (FSH) of the patients, analyzed the correlation of the serum AMH level with the other parameters, and compared the AMH level among different groups.
RESULTS:The serum AMH level was found to be correlated positively with the total sperm count (r = 0.227, P <0.001), sperm concentration (r = 0.215, P <0.001), sperm motility (r = 0.111, P = 0.003), the percentage of PMS (r = 0.120, P = 0.001), and the levels of INH-B (r = 0.399, P <0.001) and TT (r = 0.184, P = 0.002), negatively with the FSH level (r = －0.283, P <0.001), but insignificantly with age, time of abstinence, semen volume, and the percentage of MNS (P >0.05). There was a statistically significant difference in the serum AMH level among the patients with non-obstructive azoospermia, oligozoospermia, and normal sperm concentration (［6.33 ± 4.26］ vs ［8.26 ± 3.98］ vs ［9.8 ± 5.19］ ng/ml, P <0.001).
CONCLUSIONS:Serum AMH is a biomarker reflecting the function of Sertoli cells and its level is significantly correlated with sperm concentration and motility, suggesting that AMH may be involved in spermatogenesis and sperm maturation.
